The Y-strain, a Pseudomonas aeruginosa strain, holds a closeness score of 10 due to its pivotal role in microbiome research. This strain has been instrumental in groundbreaking discoveries about bacterial interactions, biofilm formation, and antibiotic resistance. Prominent researchers such as George O’Toole, Kim Lewis, and Barry Kreiswirth have extensively employed this strain in their investigations, contributing to the field’s advancement. The work conducted at institutions like Brigham and Women’s Hospital and Harvard Medical School, in collaboration with journals like Nature Microbiology, has furthered our understanding of microbial communities and their significance in health and disease.