Lymphoid aggregates are specialized immune structures located throughout the body, particularly in areas of mucosal surfaces and the respiratory and digestive tracts. They are composed of various immune cell types, including lymphocytes, macrophages, and dendritic cells, and serve as important sites for immune surveillance and response. These aggregates include Peyer’s patches in the small intestine, gut-associated lymphoid tissue (GALT), bronchus-associated lymphoid tissue (BALT), and mucosa-associated lymphoid tissue (MALT), which play crucial roles in initiating and processing immune reactions against antigens encountered in the environment. Their proper function is essential for maintaining mucosal immunity and overall immune protection.