In-hand manipulation skills entail controlling and maneuvering objects using fine motor abilities. These abilities involve hand strength, finger dexterity, grasping, pinching, and tool use. Physiological processes like proprioception, tactile perception, and visual input facilitate these skills, along with cognitive functions such as attention, planning, and visual-spatial reasoning. These skills are crucial for activities of daily living, play, and impact functional outcomes in various clinical conditions like cerebral palsy and Parkinson’s disease.